![]() ![]() Modeling and Optimization I: Usability of Response Surface Methodology. Journal of Food Measurement and Characterization 12, 1107-1122. Ethanolic Extraction of Bioactive Compounds from Vernonia amygdalina Leaf Using Response Surface Methodology as an Optimization Tool. Based on the result, total flavonoid content can be significantly increased by optimizing the MAE process use RSM.Īlara, O.R., Abdurahman, N.H., and Olalere, O.A., 2018. This value approaches to the flavonoid content obtained experimentally at 0.2961% under condition of 450 watts microwave power, 50% ethanol concentration, and time extraction of 8 minutes. The research showed that optimum extraction condition was at 414 watts of microwave power, 50.33% ethanol concentration, and time extraction of 7.89 minutes yielded a predicted value of total flavonoid content of 0.2963%. ![]() The Box-Behnken design (BBD) was used to evaluate the influence of 3 factors with 3 levels extraction that is microwave power (300, 450, 600 watts), ethanol concentration (30, 50, 70%), and extraction time (7, 8 and 9 minutes) with 15 different runs. Optimum extraction condition was determined by the response surface methodology (RSM). The sample collected from Bayah coastal waters, Banten Indonesia. Microwave-Assisted Extraction (MAE) was done to extraction flavonoid from Padina australis brown algae simplicial. Optimization of Microwave-Assisted Extraction for Total Flavonoid Content of Padina australis Brown Algae. Berdasarkan hasil penelitian, kadar flavonoid total dapat meningkat secara signifikan dengan melakukan optimasi proses MAE menggunakan RSM. Nilai ini mendekati nilai kadar flavonoid yang diperoleh secara eksperimental sebesar 0,2961%, pada kondisi menggunakan daya microwave sebesar 450 watt, konsentrasi etanol 50% dengan lama ekstraksi 8 menit. Hasil disain eksperimen dengan BBD menunjukkan kondisi ekstraksi optimum yaitu pada daya microwave 414 watt, konsentrasi etanol 50,33% dan waktu ekstraksi 7,89 menit menghasilkan kadar prediksi flavonoid sebesar nilai 0,2963%. Desain Box-Behnken (BBD) digunakan untuk mengevaluasi pengaruh 3 faktor dengan 3 level yaitu daya microwave (300, 450, 600 watt), konsentrasi etanol (30, 50, 70%), dan waktu ekstraksi (7, 8 dan 9 menit) dengan 15 perlakuan yang berbeda. ![]() Kondisi optimal ekstraksi ditentukan dengan Response Surface Methodology (RSM). Sampel diperoleh dari Pantai Bayah, Banten Indonesia. Metode Microwave-Assisted Extraction (MAE) digunakan untuk mengekstraksi senyawa flavonoid dari simplisia alga coklat Padina australis. ![]()
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